Formulation and in-vitro evaluation Rutin Phytosomes

Authors

  • Adity Sen Pal Research Scholars, SunRise University, Alwar, Rajasthan, India
  • Sweta Goel Research Supervisor, SunRise University, Alwar, Rajasthan, India
  • Manmeet Singh Saluja Research Supervisor, SunRise University, Alwar, Rajasthan, India

Keywords:

Rutin

Abstract

Rutin, a naturally occurring bioflavonoid with potent antioxidant and therapeutic properties, suffers from poor water solubility and limited bioavailability, restricting its clinical applications. To overcome these limitations, the present study aimed to develop and evaluate rutin-loaded phytosomes using a lyophilization technique. Rutin phytosomes were formulated using different molar ratios of rutin and soy phosphatidylcholine (SPC) and characterized for particle size, polydispersity index (PDI), zeta potential, drug content, and in-vitro drug release. The optimized phytosomal complex showed improved particle uniformity, stability, and high drug entrapment efficiency. Characterization techniques such as FTIR, DSC, XRD, SEM, TEM, AFM, and [1] H-NMR were employed to confirm the formation and morphological properties of the complex. The in-vitro release study demonstrated a sustained and enhanced release profile of rutin from the phytosomal system compared to pure rutin. These results suggest that rutin phytosomes may serve as an effective delivery system for improving the solubility, stability, and therapeutic efficacy of rutin.

Keywords: Rutin, Phytosomes, Bioavailability, Drug delivery, Soy phosphatidylcholine

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Published

2025-07-01

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Section

Articles