Journal of Drug Discovery and Therapeutics

Analyzing the Instabilities of Tokamak Plasma

Hashmi Sayed Taha, Puranaik Shankar Naik — Fri, 10 Nov 2023 00:00:00 -0500

Large-scale fusion reactions may be produced in the tokamak by magnetically confining the fusion fuel at a high enough density and temperature, or in the plasma state. However, turbulence causes high temperature plasma to reach the Scrape-Off Layer (SOL), the outermost layer of the tokamak with open magnetic field lines channeling particles and heat into a specific area of the vacuum vessel. A primary objective of the ITER project is to show a high gain of fusion power in a tokamak. Metallic plasma-facing components in ITER are selected because to their high heat load tolerance and minimal tritium retention. The operation of tokamaks with metallic components confronting the plasma, however, presents challenges for the management of high-Z impurities, as the build-up of heavy impurities, such tungsten (Z=74), in the plasma core results in large radiation losses and weakens the energy confinement. Tungsten (W) transport in ITER's core region (P < 0.3), is anticipated to be governed by turbulent and neoclassical processes, which are highly dependent on temperature, rotation patterns, and the primary ion density.

Keywords Tokamak, Plasma, ITER, Electricity

Constitutional Perspectives, Judicial and Legislature Measures and International Scenario of Child Sexual Abuse

Vidhya N, Sayyad Ismail — Fri, 10 Nov 2023 00:00:00 -0500

There is a major and widespread issue of child sex abuse (CSA) in India, as there is in many other countries throughout the globe today. Some children and teenagers may never recover from the psychological and emotional scars left behind by sexual abuse, which may cause developmental delays and a slew of other problems. Without the protection and therapy that children require when sexual assault is not reported, they suffer in silence. A review of recent research on child sex abuse in India is presented in this article. The CSA's socio-cultural and familial risk factors are taken into consideration here. Sexual abuse has been linked to a variety of symptoms and diseases. Consider these points while working with children who have been sexually abused in India. Data from social science and Indian legal precedents on child sexual abuse are analysed for this dissertation.

Keywords: Child, Abuse, Sex, Teenager, Symptoms, Sexual, Assault

Relationship between Emotional Expression and Psychological Distress

Aditi Purohit, Yogendra Nath Chaubey — Mon, 30 Oct 2023 00:00:00 -0400

Introduction: Cultural standards and norms are acquired via the process of socialization, which involves the transmission of knowledge and values from families, educational institutions, and society at large.

Aim of the study: the main aim of the study is to Relationship Between Emotional Expression and Psychological Distress

Material and method: The first data screening process revealed the absence of any input mistakes.

Conclusion: The results of this research provide partial support for a comprehensive dimensional model proposing that emotions may be organized into a lower-dimensional space, namely along the positive-negative continuum.

Keywords: Cultural, Emotional, Expression, Psychological, Distress

Analytical Method Development and Validation of Antimicrobial Agent by RP HPLC

Sanket B Marke, Vinayak M Shejol, Mukesh W Babhulkar, Rahul A Darakhe — Thu, 30 Nov 2023 00:00:00 -0500

To determine thirteen specific pharmaceutical compounds (metformin, amoxicillin, chloroquine, theophylline, trimethoprim, caffeine, norfloxacin, ciprofloxacin, acetylsalicylic acid, doxycycline hyclate, metronidazole, albendazole, and cloxacillin) in bulk and tablet dosage form, this study set out to develop and validate an HPLC method. The chosen target compounds were completely separated by chromatographic separation using a Kromasil C18 column, gradient elution with aqueous formic acid (0.1%), methanol, and acetonitrile, a UV absorption wavelength of 250 nm, and a mobile phase flow rate of 1 mL/min over a 22-minute run time. The author has provided a quick overview of the history of chromatography, the many kinds of chromatographic methods, uses of chromatography, and the requirement of medicines in human existence. Additionally, the author has briefly explained the significance of analytical chemistry in the pharmaceutical sector. This chapter specifies the goal of the current study and primarily explains the RP-HPLC procedure, the processes in method development, and the validation parameters of the suggested technique

Bounded Rationality in Artificial Intelligence to Sensing

Sagar Choudhary, Sunil Damodhar Rathod — Thu, 30 Nov 2023 00:00:00 -0500

The field of artificial intelligence (AI) has made significant strides in mimicking human cognitive processes, yet the concept of bounded rationality introduces a realistic lens through which AI systems approach decision-making, especially in the realm of sensing. Bounded rationality acknowledges the inherent limitations faced by AI systems in accessing complete information, allocating resources, and processing data in real-time. This abstract explores the implications of bounded rationality on AI systems engaged in sensing tasks within dynamic environments. In sensing applications, AI systems rely on various sensors to collect data from their surroundings. However, these systems often operate under constraints, such as limited computational resources, energy availability, and time pressure. Bounded rationality prompts a shift in perspective, emphasizing the need for adaptive and flexible decision-making processes that can effectively navigate uncertainties. The challenges posed by bounded rationality underscore the importance of developing algorithms that strike a balance between accuracy and computational efficiency. As AI continues to be integrated into various applications, understanding and addressing these challenges will be critical for the successful deployment of intelligent systems in real-world, dynamic environments. In conclusion, this abstract provides an overview of the impact of bounded rationality on AI systems engaged in sensing tasks. By recognizing and embracing the constraints inherent in decision-making processes, researchers and developers can pave the way for more realistic, efficient, and adaptable AI systems that navigate the complexities of dynamic environments.

Keywords: Artificial, Intelligence, Rationality, Bounded, Rationality, Decision-making, Sensing.

Study on Medicinal Plants for Antidiabetic Effects in Cataract Patients

Vidhi Jain, U.T. Jadhao — Thu, 30 Nov 2023 00:00:00 -0500

This analytical study aims to investigate the potential antidiabetic effects of medicinal plants in the context of cataract development, comparing outcomes between diabetic and non-diabetic individuals. Diabetes is a known risk factor for cataract formation, and exploring the efficacy of medicinal plants in managing diabetes-associated cataracts is of significant interest. The research involves a comprehensive analysis of various medicinal plants with documented antidiabetic properties, assessing their impact on cataract progression in diabetic and non-diabetic subjects. The study employs both clinical and biochemical parameters to evaluate the effectiveness of these medicinal plants in mitigating cataract development, shedding light on their potential as adjunctive therapeutic interventions in diabetic eye complications.

Keywords: cataract, diabetes mellitus, oxidative stress, superoxide dismutase enzyme.

Medicinal Plants Used for Diabetes Mellitus: A Short Review

Prashant Kumar, Richa Mishra — Thu, 30 Nov 2023 00:00:00 -0500

Investigating the antidiabetic effects of different medicinal plants is the focus of the current study. Among the many non-communicable illnesses that affect people across the world, diabetes mellitus ranks high. Although it has not yet reached pandemic proportions in many poor and newly industrialized nations, it is now the fourth worst killer among the world's wealthiest countries. We must confront this grave danger in the twenty-first century. Herbs and plants have been used as medicine for a very long time. Plants were referenced in Ayurveda and other Indian texts as potential treatments for a variety of illnesses. Less than one percent of the approximately 250,000 higher plants have undergone pharmacological screening, with even less tested for diabetes mellitus. There has been a dearth of systematic research on the traditional medicinal herbs used to treat diabetes mellitus.

Evaluation of Natural Language Processing and Machine Learning

PV Ramana Murthy, Rakesh Kumar Giri — Wed, 29 Nov 2023 00:00:00 -0500

Natural language processing, or NLP, is a set of computer methods that are based on theories and are used to automatically understand and describe human conversation. The main aim of the study is to Evaluation of Natural Language Processing and Machine Learning. Pre-processing of text features and pre-processing of numerical and category characteristics are the two primary components that make up the bulk of the data pre-processing procedure. In this study, a classification system for technical papers as well as an assessment strategy for document quality rankings are presented.

Keywords: Natural, Language, Pre-processing, Primary, Document, Numerical.

Prosopis Cineraria as Hepatoprotective: A Review

Rajesh Asija, Amandeep Swami, Vishwaroop Singh — Thu, 30 Nov 2023 00:00:00 -0500

Prosopis cineraria (L.) Druce, belonging to the Leguminosae family's Mimosoideae subfamily, is referred to as Ghaf. The herb has sociological, ethnological, traditional, and medicinal effects on people's lives. The idea is to provide an overview of the most recent research with detailed information, emphasizing the plant's potential for bioactivity. The goal of the review was to update the data on therapeutic activities that had been published in scientific journals and to offer a thorough tabulation of the data in a format that would be helpful to academic researchers. A thorough scientific investigation of P. cineraria (L.) was conducted to determine the phytochemical constituents of the leaf, stem, pod, and bark as well as their safety and pharmacological information. Using the condensed scientific knowledge of P. cineraria (L.), the review aids in identifying gaps in the field and future opportunities.

Keywords: Prosopis Cineraria, Leguminosae, Ghaf, Phytochemical, Pharmacological

Prosopis Cineraria as Hepatoprotective: A Review

Rajesh Asija, Amandeep Swami, Rochak Jha — Thu, 30 Nov 2023 00:00:00 -0500

In the ever-evolving landscape of pharmaceuticals, innovative drug delivery systems continue to emerge, seeking to optimize treatment outcomes and patient experiences. Gastric floating beads, a pioneering development, have garnered substantial attention due to their unique ability to transform drug delivery. This abstract provides a concise overview of gastric floating beads, their innovative design, applications, advantages, challenges, and future potential. Gastric floating beads are engineered microspheres designed to remain buoyant within the stomach, facilitating controlled and prolonged drug release. Comprising a hydrophobic polymer matrix and a gas-generating agent, these beads harness the production of carbon dioxide upon exposure to gastric acid, rendering them buoyant and capable of targeted drug delivery. The applications of gastric floating beads span a spectrum of pharmaceutical needs. They are particularly well-suited for extended drug release, offering a consistent and sustained therapeutic effect. Their buoyant nature allows for targeted drug delivery within the stomach, thereby improving drug bioavailability while reducing systemic side effects. Simplified dosing schedules enhance patient adherence, a vital factor in the success of many treatment regimens. The revolutionary mechanism of gastric floating beads is rooted in their design. The interaction between the gas-generating agent and gastric acid initiates the release of carbon dioxide, creating a low-density environment that enables the beads to float on the gastric fluid. This unique feature supports their ability to dispense drugs at a controlled rate, optimizing their absorption through the stomach lining.

Keywords: Floating Beads, Prolonged, Gastric Fluid, Microspheres, Advantages