Journal of Drug Discovery and Therapeutics https://www.jddt.in/index.php/jddt <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>(Scientific Journal Impact Factor Value for 2021)</strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>SJIF 2021 = 6.104 </strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. 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LIB) Mon, 02 Sep 2024 15:04:15 +0000 OJS 3.2.1.1 http://blogs.law.harvard.edu/tech/rss 60 A Research on Formulation, Characterization and Evaluation of Pre-Formulation Studies and Pre - Compressional Parameters of Anti -Hypertensive Drug Losartan Potassium by using Locust Bean Gum as Super-Disintegrant https://www.jddt.in/index.php/jddt/article/view/590 <p style="font-weight: 400;">Patients who struggle to swallow pills, capsules, or other oral medications might find relief using fast-dissolving drug delivery devices. Fast-dissolving pills can be eaten without the assistance of water since they dissolve instantly in the mouth. The purpose of the current work was to use locust bean gum as a natural super disintegrant in pre-formulation trials of the medication losartan potassium. Conduct pre-formulation research on the drug's identification, solubility, and partition coefficient. Precompressional characteristics, such as angle of repose, swelling index, and micromeritic properties, can have an impact on tablet formulation in addition to the drug's characterisation, compatibility, and melting point.</p> <p style="font-weight: 400;"><strong>Material and methods: </strong>Losartan potassium was received as gift sample from Elfin drug pvt ltd baddi, nalagarh (Himachal Pradesh). Locust bean gum was purchased from Lucid colloids, Mumbai. Microcrystalline cellulose (avice1102), aspartame and magnesium stearate was received as gift sample from helios pharmaceutical pvt. ltd. baddi (H.P). Menthol was purchased from Yarrow Chem. Mumbai (Maharashtra) and talc was purchased from Qualichems Fines Chemicals ltd New Delhi.</p> <p style="font-weight: 400;"><strong>Result:</strong> The results suggested that locust bean gum in 7.5% concentration possess excellent super disintegrant property and resulted in fast dissolving tablets. Swelling index was found to be 22 which indicated appreciable capability of locust bean gum to be used as super disintegrant. IR spectra and DSC study showed that there was no any kind of interaction with formulation additives of the tablets.</p> <p style="font-weight: 400;"><strong>Conclusion: </strong>Based on the pre formulation studies locust bean gum show a super disintegrant properties and it is clear that we can formulate fast dissolving antihypertensive tablet with losartan potassium by using locust bean gum as superdisintegrant.</p> <p><strong>Key words</strong>: Super disintegrant, preformulation, fast dissolving tablets (FDT<sub>S</sub>), locust bean gum, losartan potassium.</p> Kehar Singh, Amit Kumar, Satbir Singh Copyright (c) 2024 Journal of Drug Discovery and Therapeutics https://www.jddt.in/index.php/jddt/article/view/590 Mon, 02 Sep 2024 00:00:00 +0000 A Research on Formulation Development of Sustained Release Antiulcer Drug Nizatidine and Study of Pre-Formulation Parameters and Its Evaluation https://www.jddt.in/index.php/jddt/article/view/591 <p style="font-weight: 400;">The current study's objective was to create sustained release tablets containing 220 mg of nizatidine by adjusting the concentration of polymers such as chitosan, HPMC K100M, and Kollidon SR using a wet granulation approach. The drug's melting point, FTIR analysis, and DSC analysis were among the pre-formulation factors that were investigated. Pre-compression characteristics such as bulk density, taped density, carry index, and angle of repose were assessed. The concept on how the concentration of polymers influences the drug formulation's pre-compression parameters was made clear by this study.</p> <p><strong>Keywords: </strong>Pre-formulation, characterization, Sustained Release, Antiulcer Drug, Nizatidine, Chitosan, HPMC K100, Kollidon SR.</p> Satbir Singh, Amit Kumar, Kehar Singh Copyright (c) 2024 Journal of Drug Discovery and Therapeutics https://www.jddt.in/index.php/jddt/article/view/591 Mon, 02 Sep 2024 00:00:00 +0000 Synthesis, Characterization and Antimicrobial Screening of Oxazolopyridine Derivatives https://www.jddt.in/index.php/jddt/article/view/593 <p style="font-weight: 400;">Modifications on the benzoxazole nucleus have resulted in a large number of compounds having diverse pharmacological activities. The synthesis, structures and biological activities of benzoxazole derivatives have long been focused of research interest in the field of medicine, due to potential activities exhibited by them. The biological profiles of these new generations of benzoxazole represent much progress with regards to older compounds. Looking into the medicinal importance of benzoxazole moiety, it will be worthwhile to synthesize certain newer derivatives of benzoxazole and screen them for their biological activities.</p> <p><strong>Keywords: </strong>Benzoxazole, Synthesis, Structure</p> Shiv Shankar Kumar, Ketkee Mandawar, Govind Nagar, Pratyush Jain Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/593 Tue, 17 Sep 2024 00:00:00 +0000 Formulation and Evaluation of Solid Lipid Nanoparticles Containing Fenoprofen https://www.jddt.in/index.php/jddt/article/view/592 <p style="font-weight: 400;">The biggest challenge up to date is to control the delivery rate of the medicaments by various modern technologies met by extensive research. However, TDS is not practical for delivery of materials whose final target is the skin itself. The oral administration of fenoprofen causes gastrointestinal ulcers and bleeding in chronic use. Due to gastrointestinal bleeding, it may cause anaemia. Also, use of fenoprofen is limited by its poor solubility and low bioavailability. Thus,&nbsp; the&nbsp; present&nbsp;study&nbsp; aimed&nbsp; at &nbsp;design&nbsp; and&nbsp; development of a drug delivery system which could&nbsp; enhance&nbsp; the&nbsp; solubility&nbsp; of&nbsp; fenoprofen.</p> <p><strong>Keywords: </strong>Gastrointestinal, Bioavailability, Fenoprofen</p> Sanjay Kumar Tiwari, Rishab Shukla, Supyar Singh Copyright (c) 2024 Journal of Drug Discovery and Therapeutics https://www.jddt.in/index.php/jddt/article/view/592 Wed, 18 Sep 2024 00:00:00 +0000