https://www.jddt.in/index.php/jddt/issue/feed Journal of Drug Discovery and Therapeutics 2024-05-17T16:31:38+00:00 JDDT-PUBLISHER editor@jddt.in Open Journal Systems <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>(Scientific Journal Impact Factor Value for 2021)</strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>SJIF 2021 = 6.104 </strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JDDT only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jddt.in</strong>, <strong>editorjddt.in@gmail.com</strong></span></span></p> <p> </p> https://www.jddt.in/index.php/jddt/article/view/535 COVID-19: A REVIEW 2024-04-08T04:07:27+00:00 Jaswinder . editor@jddt.in Rajesh Kumar editor@jddt.in Ajeetpal Singh editor@jddt.in Amarpal Singh editor@jddt.in Himani Rana editor@jddt.in <h1>The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a significant global health crisis, challenging healthcare systems, economies, and societies worldwide. In this comprehensive review, we elucidate the epidemiology, transmission dynamics, clinical manifestations, and pathogenesis of COVID-19. We summarize the current understanding of the virus-host interaction, immune response, and viral pathogenic mechanisms underlying the disease severity spectrum, ranging from asymptomatic infection to severe pneumonia and acute respiratory distress syndrome (ARDS). Furthermore, we discuss diagnostic modalities, therapeutic interventions, vaccine development efforts, and public health strategies implemented to control the spread of the virus. This review aims to provide a holistic perspective on COVID-19, highlighting the urgent need for continued research and global collaboration to mitigate the ongoing pandemic and prepare for future emerging infectious diseases..</h1> <p><strong>Keywords: </strong>ARDS., SARS-CoV-2</p> 2024-04-05T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/536 ANTICONVULSANT DRUGS (Classification and it’s mechanism of action): A REVIEW 2024-04-08T04:26:39+00:00 Preekdeep Kaur EDITOR@JDDT.IN Rajesh Kumar EDITOR@JDDT.IN Ajeet Pal Singh EDITOR@JDDT.IN Amarpal Singh EDITOR@JDDT.IN Prachi Sharma EDITOR@JDDT.IN <p style="font-weight: 400;">Anticonvulsant drugs play a crucial role in managing a spectrum of neurological conditions beyond epilepsy. They work by stabilizing electrical activity in the brain through various mechanisms, such as blocking sodium and calcium channels, enhancing inhibitory neurotransmitter activity, and antagonizing excitatory neurotransmitter receptors. While effective in controlling seizures, anticonvulsants can cause side effects like drowsiness, dizziness, and gastrointestinal disturbances. Long-term use may lead to cognitive impairment and liver toxicity. These medications are also utilized in the treatment of neuropathic pain, bipolar disorder, and migraine prophylaxis. In neuropathic pain management, drugs like gabapentin and pregabalin are commonly prescribed due to their ability to modulate neuronal excitability and reduce pain signals. Additionally, certain anticonvulsants, such as valproate and carbamazepine, have mood-stabilizing properties and are used as adjunctive therapy for bipolar disorder. Furthermore, topiramate, another anticonvulsant, has demonstrated efficacy in preventing migraines and is often prescribed for migraine prophylaxis. Thus, anticonvulsant drugs contribute significantly to the therapeutic armamentarium for various neurological and psychiatric conditions beyond epilepsy.</p> <p><strong>Keywords: </strong>Epilepsy, Anticonvulsant drugs, mechanism of action, commonly used anticonvulsants.</p> 2024-04-04T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/537 Diuretics: A Review 2024-04-10T04:24:23+00:00 Kajal Kumari editor@jddt.in Rajesh Kumar editor@jddt.in Ajeet Pal Singh editor@jddt.in Amar Pal Singh editor@jddt.in Prachi Sharma editor@jddt.in <p>Diuretics represent a cornerstone in managing various conditions by enhancing diuresis and natriuresis. Acting at different segments of the renal tubule, they offer a versatile approach to fluid management. Loop diuretics, such as acetazolamide, find utility in acute heart failure, exerting antihypertensive effects and mitigating fluid overload with minimal electrolyte disturbances. Thiazide and thiazide-related diuretics, while effective antihypertensives, warrant vigilance due to potential complications like hyponatremia and hypokalemia. In contrast, mineralocorticoid receptor antagonists exhibit multifaceted benefits, including antihypertensive, nephroprotective, and cardioprotective effects, albeit increasing the risk of hyperkalemia. In contrast, mineralocorticoid receptor antagonists exhibit multifaceted benefits, including antihypertensive, nephroprotective, and cardioprotective effects , albeit increasing the risk of hyperkalemia. SGLT2 Inhibitors emerge as promising agents with antihypertensive and cardio-renal protective effects, without adverse impacts on natremia. Understanding the mechanisms and clinical implications of diuretics is crucial for optimizing therapeutic strategies in conditions such as heart failure, nephrological disease, and hypertension.</p> 2024-04-08T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/538 Review article on Niosomes and their future 2024-04-10T04:28:28+00:00 Mahesh Sehgal EDITOR@JDDT.IN Rajesh Kumar EDITOR@JDDT.IN Ajeet Pal Singh EDITOR@JDDT.IN Amarpal Singh EDITOR@JDDT.IN Prachi Sharma EDITOR@JDDT.IN <p>Over the past decade, a significant number of review and research articles have been published on niosomes. This demonstrates the keen interest of researchers in niosomes due to their advantageous characteristics compared to other vesicular carrier systems. Niosomes are formed through the self-assembly of non-ionic surfactant vesicles. Various factors, such as the type of non-ionic surfactant used, method of preparation, and temperature of hydration, influence the formation of niosomes. In this comprehensive review article, we aim to encompass all essential aspects of niosomes, including different preparation methods, types of niosomes, factors influencing their formation, niosome characterization, applications, routes of administration, and recent advancements in niosomal research. Additionally, we provide a literature review of research conducted in the past decade.</p> 2024-04-02T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/539 Anitibiotics –Beta Lactums: A Review 2024-04-10T04:32:36+00:00 Harmandeep Kaur EDITOR@JDDT.IN Rajesh Kumar EDITOR@JDDT.IN Ajeet Pal Singh EDITOR@JDDT.IN Amarpal Singh EDITOR@JDDT.IN Prachi Sharma EDITOR@JDDT.IN <p style="font-weight: 400;">Antibiotics are medicines that help stop infections caused by bacteria. They do this by killing the bacteria or by keeping them from copying themselves or reproducing. The word antibiotic means against life. Any drug that kills germs in your body is technically an antibiotic.</p> <p style="font-weight: 400;">&nbsp;Antibiotics are classified into one of the following classes: penicillins, fluoroquinolones, cephalosporins, macrolides, beta-lactams with increased activity (e.g. amoxicillin-clavulanate), tetracyclines, trimethoprim-sulfamethoxazole, lincosamides (e.g. clindamycin), urinary anti-infectives, and other antibiotics</p> <p style="font-weight: 400;">Beta lactum antibiotics (Penicillins, Cephalosporins, Monobactams, and Carbapenems) mainly act by interrupting bacterial cell wall formation&nbsp;as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in the terminal steps of peptidoglycan cross-linking in both Gram-negative and Gram-positive bacteria.</p> <p><strong>Key Words:</strong> Antibiotics, penicillins, fluoroquinolones, cephalosporins, macrolides, beta-lactams.</p> 2024-04-03T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/540 Neuroprotective Herbal Plants - A Review 2024-04-12T11:58:19+00:00 Swayam Sampurna Mohanty editor@jddt.in Amit Kumar editor@jddt.in <p style="font-weight: 400;">The goal of neuroprotection is to shield neurons against damage, whether that damage is caused by environmental factors, pathogens, or neurodegenerative illnesses. Inhibiting protein-based deposit buildup, oxidative stress, and neuroinflammation, as well as rectifying abnormalities of neurotransmitters like dopamine and acetylcholine, are some of the ways in which medicinal herbs have neuroprotective effects [1-3]. This review will focus on the ways in which medicinal herbs may protect neurons.</p> <p><strong>Keywords: </strong>Neuroprotective; Medicinal plants; CNS; Neurons.</p> 2024-04-10T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/541 Neuroprotective Plants: A Review 2024-04-12T12:01:03+00:00 Hrishikesh Chaturvedi EDITOR@JDDT.IN Amit Kumar EDITOR@JDDT.IN <p style="font-weight: 400;">Enhanced oxidative stress in the central nervous system (CNS) is a consequence of an overactive metabolism and an inadequate antioxidant defence mechanism. More and more evidence from experiments suggests that reactive oxygen species (ROS) have a role in neurodegenerative diseases. The term "neuroprotection" describes measures taken to keep neurones' structures and functions intact in the face of threats from cellular damages brought on by various chemicals or neurological illnesses. Several neurodegenerative diseases, such as schizophrenia, depression, Alzheimer's disease, dementia, cerebrovascular impairment, seizure disorders, parkinsonism, and head injuries, may severely limit a person's ability to operate. These disorders may be reduced or avoided with the use of antioxidants, which inactivate them. The ancient Indian medicinal practice of Ayurveda has linked the antioxidant and neuroprotective effects of some plants to a range of health benefits. An ancient medical system known as Ayurveda has found a number of plants that have antioxidant and therapeutic effects on neurological diseases. Research has shown that extracts from Bacopa monniera may boost cognitive function in humans. Bacopa extract has antioxidant qualities, according to reports. Research has shown that ginkgo biloba may reduce free oxygen radical levels. Withania somnifera extracts improve antioxidant status in oxidative stress-induced neurodegeneration. It is still need to investigate many more plants to see whether they possess any neuroprotective properties. According to the study, many of the medicinal plants used in Ayurveda and Chinese medicine have a wide range of components and phytochemicals that may have a neuroprotective effect. This might be useful in the treatment of neurodegenerative and neuropsychiatric diseases.</p> <p><strong>Keywords: </strong>Neuroprotection; Antioxidant; Neurodegenerative disease; Medicinal herbs.</p> 2024-04-10T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/542 Simran Saini *, Rajesh kumar, Ajeet Pal Singh, Amar Pal Singh & Meenakshi Malhotra 2024-04-12T12:03:32+00:00 Simran Saini EDITOR@JDDT.IN Rajesh Kumar EDITOR@JDDT.IN Ajeet Pal Singh EDITOR@JDDT.IN Amar Pal Singh EDITOR@JDDT.IN Meenakshi Malhotra EDITOR@JDDT.IN <p>The microsphere is spherical microparticles and is used where consistent and predictable particle surface area is important. A microsphere has a unique polymeric membrane encasing a centrally located drug in it. Microsphere drug delivery system has gained enormous attention not only for prolonged release but also due to its wide range of application as it covers targeting the drug to a particular site to imaging and helping the diagnostic features. Today by combining various other strategies, microspheres have found the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene &amp; genetic materials, safe, targeted, and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. This review compiles various types of microspheres, polymers used, different preparation methods, Factors influencing, various parameters to evaluate their efficiency, its applications, and also some Recent Advancements in Microspheres.</p> 2024-04-11T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/547 The Patient Counseling and Patient Medication History Interview -A Review 2024-05-06T13:18:30+00:00 Jyotirmoy Deb jyotirmoydev@gmail.com Mohibur Rahman jyotirmoydev@gmail.com Jisu Das editor@jddt.in Bapan Banik editr@jddt.in Nargis Sultana editor@jddt.in Bapan Sarkar editor@jddt.in <p style="font-weight: 400;">The skill of communication between patients and pharmacists has a significant impact on the procedure of medication counselling. The current vivid review provides a thorough practical loom in conducting the effective patient medication interview. The reason of this study was to assess pharmacist’s practices of medication counselling. Communicate with the patient in a manner that encourages the respect for the healthcare provider and that enables the pharmacist to obtain an accurate and complete history. Communication skills and questioning techniques, especially when it comes to communicating with patients, are learned and take time to develop. Interpersonal communication plays a key role in the healthcare behaviour change process. Good communication between a patient and their pharmacist leads to an overall improvement in physical health, chronic disease management, and a better quality of life in regards to patient health.</p> <p><strong>Keywords:</strong> Counselling, medication interview, complete history, healthcare, communication skills</p> 2024-04-30T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/546 Stability Indicating UPLC Method for Quantifying Assay of Letrozole 2024-05-06T12:55:38+00:00 Pawar Geetanjali Raosaheb editor@jddt.in Sourobhi Datta editor@jddt.in <p style="font-weight: 400;">Letrozole, an aromatase inhibitor, is widely used in the treatment of hormone receptor-positive breast cancer. Ensuring the stability and accurate quantification of letrozole is crucial for its efficacy and safety in clinical practice. In this study, a stability indicating Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the quantitative determination of letrozole in pharmaceutical formulations. The UPLC method utilized a reverse-phase C18 column with a mobile phase consisting of acetonitrile and 0.1% formic acid in water, delivered in an isocratic mode at a flow rate of 0.5 mL/min. Detection was performed at a wavelength of 240 nm. The method exhibited excellent linearity over the concentration range of 5-100 μg/mL (r2 = 0.999), with a limit of detection (LOD) of 1 μg/mL and a limit of quantification (LOQ) of 5 μg/mL. The stability indicating capability of the method was demonstrated through forced degradation studies under various stress conditions, including acidic, basic, oxidative, thermal, and photolytic stress. Letrozole remained stable under all stress conditions, with no significant degradation observed. Additionally, the method showed good selectivity, specificity, precision, accuracy, and robustness in the quantification of letrozole. Overall, the developed UPLC method provides a reliable and sensitive approach for the quantitative determination of letrozole in pharmaceutical formulations. Its stability indicating nature ensures the accurate assessment of letrozole stability and potency, thereby facilitating quality control and assurance in the production and use of letrozole-containing medications.</p> <p><strong>Keywords: </strong>Letrozole, Photolytic, Stress, Quantification, Pharmaceutical.</p> 2024-04-18T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/548 Evaluation of Cordia dichotoma Gum as a Potent Excipient for Formulation of Film 2024-05-11T13:59:42+00:00 Vaibhav Mangalrao Darvhekar editor@jddt.in A. V. Chandewar editor@jddt.in <p style="font-weight: 400;">Films were prepared (viz. CDF1, CDF2, CDF3, CDF4, CDF5) using 5 parts of 10% w/w of mucilage of gum of <em>Cordia dichotoma</em> with different proportions of plasticizers methyl paraben, glycerine. The films were casted on mercury plate. Films prepared with different proportion of gum and 0.2 % w/v methyl paraben, 2.5% w/v of glycerine showed satisfactory drying after 24 h. They were evaluated for qualitative phytochemical analysis followed by mechanical properties like water uptake, tensile strength, folding endurance, and water vapor transmission rate and stability studies also done for plane film. Further the gum was evaluated for release parameter with model drug diclofenac sodium (0.5 % w/w) with same composition of methyl paraben and glycerine.</p> <p style="font-weight: 400;">Study found that the CDF3 film shows the best result among other batches of <em>Cordia dichotoma. </em></p> <p><strong>Key word: </strong><em>Cordia dichotoma, </em>natural gum<em>, </em>film<em>, </em>sustained release drug delivery systems<em>,</em> diclofenac sodium.</p> 2024-05-10T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/549 Social Media Platforms Influence Political Engagement, Activism, and Voter Behavior 2024-05-17T16:24:59+00:00 Muninder Kumar editor@jddt.in Kasturi Yadav editor@jddt.in <p style="font-weight: 400;"><strong>Introduction:</strong> People can hold their elected officials responsible and have a say in the way their country is governed when they participate in political processes, which is why political engagement is significant in democratic nations.</p> <p style="font-weight: 400;"><strong>Aim of the study: </strong>The Main Aim of The Study Is to Social Media Platforms Influence Political Engagement, Activism, And Voter Behavior</p> <p style="font-weight: 400;"><strong>Material and method:</strong> The research design is the framework that guides and organises the investigation. A research design is a detailed plan outlining how research will be conducted, including data gathering methods, measurement procedures, and data processing techniques.</p> <p style="font-weight: 400;"><strong>Conclusion:</strong> Social media is a commonly used tool that has been studied for its influence on political engagement in Western and Arab nations, but there is limited research on its impact in India.</p> <p><strong>Keywords: </strong>Social media, Platforms, Influence, Political Engagement, Activism, And Voter Behavior, etc.</p> 2024-04-30T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/550 Ananlyzing the Effects and Consequences of Sustainable Urban Development with Respect to Socio-Economic Variables 2024-05-17T16:27:29+00:00 Pratibha Singh EDITOR@JDDT.IN Shankar Lal Saini editor@jddt.in <p style="font-weight: 400;">Sustainable urban planning prioritizes the well-being of city dwellers across economic, social, and environmental dimensions without sacrificing any. More people moving from the countryside to the city means more people living in cities, which puts a pressure on city infrastructure.</p> <p><strong>Keyword:</strong> Sustainable, development, economically, movement.</p> 2024-05-10T00:00:00+00:00 Copyright (c) 2024 https://www.jddt.in/index.php/jddt/article/view/551 Role of Leadership in Shaping Successful Strategic Management Practices 2024-05-17T16:31:38+00:00 Avinash Shrestha EDITOR@JDDT.IN Rajinder Singh editor@jddt.in <p style="font-weight: 400;">For organisations to thrive and endure in today's fast-paced and cutthroat business world, sound strategic management is essential. Though approaches and tools play a significant role, leadership is the ultimate arbiter of strategic management practices. The purpose of this study is to investigate how effective leadership influences strategic management practices. Strategic success may be driven by competent leaders; this research aims to shed light on how this can be achieved by analysing the relationship between leadership styles, organisational culture, and decision-making processes.</p> <p><strong>Key</strong> <strong>words:</strong> leadership, strategic management, management practices.</p> 2024-05-11T00:00:00+00:00 Copyright (c) 2024