https://www.jddt.in/index.php/jddt <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>(Scientific Journal Impact Factor Value for 2021)</strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>SJIF 2021 = 6.104 </strong></span></span></span></p> <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JDDT only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jddt.in</strong>, <strong>editorjddt.in@gmail.com</strong></span></span></p> <p> </p> JDDT en-US Journal of Drug Discovery and Therapeutics 2320-4230 https://www.jddt.in/index.php/jddt/article/view/748 <p style="font-weight: 400;">Alzheimer’s disease (AD) is associated with cognitive decline and dementia, typically seen in the elderly due to ongoing neurodegeneration. It progressively deteriorates the patient's memory capabilities. The key diagnostic indicators include the presence of senile plaques and Neurofibrillary tangles (NFTs). A significant reduction in Acetylcholine (Ach), a neurotransmitter in the brain, occurs due to its breakdown by the enzyme Acetylcholine esterase before it can exert its effects, along with neural cell death, which are the main contributors to AD. Although there are various categories of Anti-Alzheimer’s medications available for managing AD, successful outcomes have been limited due to poor patient adherence. Additionally, incorporating Nutraceuticals into daily diets, engaging in Aromatherapy, adjusting daily routines, and practicing yoga regularly can help alleviate stress, insomnia, improve blood circulation, detoxify organs through rhythmic breathing, and reduce headache frequency, as evidenced by surveys. Currently, herbal medicine has emerged as a preferred option for managing AD due to its accessibility, cost-effectiveness, high patient compliance, ease of preparation, and minimal adverse side effects. Innovative methods can be employed to enhance the development of herbal medicine. Bacopa monnieri is a native plant that grows across India. For centuries, it has been recognized in Ayurveda as a “Medhya Rasayan” (nootropic). Research has demonstrated several effects of Bacopa monnieri, including its ability to inhibit the enzyme cholinesterase. This inhibition can lead to a reduction in the breakdown of acetylcholine, a crucial neurotransmitter, the levels of which are diminished in Alzheimer’s disease.&nbsp; key active ingredients in this plant include triterpene saponins known as bacosides, along with alkaloids like bramine and herpestine, as well as flavonoid and steroid compounds. Research conducted in vivo has demonstrated that an extract of B. monnieri containing 25% bacoside A produces an anxiolytic effect similar to that of lorazepam. While lorazepam is often associated with side effects such as amnesia, B. monnieri does not lead to these adverse effects and, in fact, offers memory-enhancing benefits.</p> <p><strong>Keywords: </strong><span style="font-weight: 400;">Alzheimer’s disease (AD), Bacopa<em> monnieri</em>, Medhya Rasayan, Bacosides A, bramine and herpestine, Neurofibrillary tangles (NFTs), Acetylcholine (Ach).</span></p> Ajeet Singh Altaf Husain Ameenuddin Ansari Avneesh Kumar Shloke Kumar Dwivedi Ahmed Abdullah Khan Copyright (c) 2026 2026-01-22 2026-01-22 14 1 1 19