Formulation and evaluation of transdermal patch containing essential oils

Abstract

This study investigates the formulation and evaluation of a herbal essential oil-based transdermal drug delivery system (TDDS) with potential anti-inflammatory and analgesic properties. The oils selected—Capsicum oleoresin, Wintergreen oil (methyl salicylate), Mentha oil (menthol), and Thymol oil—are well-known for their therapeutic activities. These oils were incorporated into transdermal patches using suitable polymers and evaluated for physicochemical parameters, and in vitro drug release. Results demonstrated that the herbal essential oil-based TDDS offers a promising alternative for pain and inflammation management with controlled drug delivery and enhanced patient compliance.

Keywords: Transdermal drug delivery system, Essential oils, Capsicum oleoresin, Wintergreen oil, Mentha oil, Thymol, Anti-inflammatory, Analgesic.