Development of a Topical Antifungal and Antibacterial Preparation Based on Ayurvedic Principless

Abstract

Background: Superficial fungal and bacterial skin infections represent a widespread global public health challenge, exacerbated by environmental humidity, poor hygiene, and mounting resistance to synthetic antimicrobials. Prolonged use of synthetic topical drugs frequently results in adverse cutaneous reactions such as hypersensitivity, localized irritation, and extreme dryness. This study details the formulation and systemic pharmaceutical evaluation of an oil-based, hydrophobic polyherbal topical lotion developed using classical Ayurvedic principles.
Methods & Materials: The lotion was prepared using a lipid base consisting of Coconut Oil (Cocos nucifera) and Beeswax, incorporating therapeutically active mineral and herbal constituents: Camphor, Sulphur, Borax, and Turmeric (Curcuma longa). Due to its hydrophobic nature and the absolute absence of water, the formulation exhibits inherently high resistance to microbial proliferation. Standard organoleptic, homogeneity, pH compatibility, and rheological parameters were measured.

Results & Conclusion: The developed preparation provides a smooth, yellow, stable semi-solid matrix with a skin-compatible pH range. It offers a synergistic multi-target therapeutic profile, combining potent antifungal, antibacterial, anti-inflammatory, antipruritic, and accelerated wound-healing dynamics with an estimated shelf life of 2 to 3 years without requiring synthetic chemical stabilizers.