FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CEFUROXIME AXETIL

Abstract

In this investigation, fast dissolving tablets of Cefuroxime Axetil were prepared using different super disintegrants. A wet granulation method was used as direct compression method unable to formulate dispersible tablet of Cefuroxime axetil. Different super disintegrant were used such as croscarmellose sodium (CCS), sodium starch glycolate (SSG) and crospovidone (CPVP). In all the formulations, water was used as a binding agent to attain hardness. The prepared fast disintegrating tablets were evaluated for weight variation, content uniformity, hardness, disintegration time, wetting time and friability of tablets. Wetting time of formulations containing sodium starch glycolate was least and tablets showed fastest disintegration. All the tablets had hardness 2.0-4.0 kg/cm2 and friability of all formulations was less than 1%, weight variation and drug content were within official limit. Amongst all formulations, formulation F5 prepared showed least disintegrating time of 21.40 secs and faster dissolution.

KEYWORDS: Cefuroxime axetil, Disintegration time, wetting time; FDT, Croscarmellose sodium, sodium starch glycolate and Crospovidone.