Chemotherapy for Cancer

Abstract

The creation of medicines, and especially chemotherapy, relies heavily on heterocyclic molecules, which are fundamental to medicinal chemistry. This research aims to increase the usefulness and efficacy of heterocyclic chemicals in the treatment of cancer. therapy by creating new synthetic techniques for these chemicals. By exploring innovative synthetic routes and methodologies, we aim to overcome existing challenges in the synthesis of complex heterocyclic structures and to discover compounds with potent anticancer properties. Our approach involves the integration of modern synthetic techniques, including biocatalysis and flow chemistry, to streamline the synthesis process, reduce environmental impact, and improve yield and purity. Biocatalysis leverages the specificity and efficiency of enzymes to facilitate reactions under mild conditions, offering a sustainable alternative to traditional chemical methods. Flow chemistry, on the other hand, allows for continuous synthesis, improving reaction control and scalability. As part of our study, we created a number of new heterocyclic compounds and tested their cytotoxicity against different types of cancer cells. A number of substances have shown promising anticancer effects in preliminary studies, demonstrating their potential as chemotherapy agents. Structure-activity relationship (SAR) studies have been conducted to understand the molecular features responsible for their efficacy, guiding further optimization of these compounds. Additionally, we have employed computational chemistry tools to predict the interaction of these heterocyclic compounds with target proteins involved in cancer proliferation. These predictions are validated through in vitro and in vivo experiments, providing a comprehensive understanding of the mechanisms of action and potential therapeutic applications.

Keywords Cancer chemotherapy, cancer stem cells mechanisms of action, side effects