A RECENT TRENDS IN ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE HYDROPHOBIC DRUGS BY USING PHYSICAL AND CHEMICAL MODIFICATIONS

Abstract

The aim of this review was to improve the solubility and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown which is defined as maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. This is true for parenterally, topically and orally administered solutions. Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Hence  this review was to described in detailed solubility, process of solubilization, factor affecting solubilization, and various recent technique used for improvement of solubility such as GAS, RESS, Nanosuspension Micro emulsion, Use of salt form of drug, micronisation, SCF, Inclusion complex, Co-solvancy Solid Dispersion.

KEYWORDS: Solubility enhancement, Poorly water soluble, solid dispersion, Techniques.