Clinical, Histomorphological, and Immunohistochemical Features of Breast Neoplasms

Abstract

Background: Breast neoplasms are a significant health concern worldwide, with varying clinical presentations, histomorphological characteristics, and immunohistochemical profiles. Understanding these aspects is crucial for accurate diagnosis and effective management.

Objective: This study aims to evaluate the clinical features, histomorphological patterns, and immunohistochemical profiles of breast neoplasms in patients.

Material and Methods: This cross-sectional study was conducted in the Department of Pathology at a tertiary care hospital over 2 years. A total of 30 patients diagnosed with breast neoplasms were included. Clinical data were collected, followed by histopathological examination and immunohistochemical staining for markers such as Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal Growth Factor Receptor 2 (HER2).

Results: The study found that invasive ductal carcinoma was the most common type of breast neoplasm, with a significant correlation between ER positivity and favorable histological grade. Immunohistochemical analysis revealed a high prevalence of ER and PR positivity in hormone receptor-positive tumors.

Conclusion: A comprehensive analysis of clinical, histomorphological, and immunohistochemical features enhances the understanding of breast neoplasms and aids in formulating personalized treatment strategies.

Keywords: Breast neoplasms, histomorphology, immunohistochemistry, estrogen receptor and progesterone receptor.