Insulin Resistance and its Association with Preeclampsia: A Comprehensive Analysis

Abstract

This study explores the relationship between insulin resistance and the development of preeclampsia in pregnant women. Preeclampsia, a pregnancy-related hypertensive disorder, poses significant risks to both maternal and fetal health. Recent evidence suggests that insulin resistance may play a pivotal role in the pathogenesis of preeclampsia.

We conducted a case-control study involving 200 pregnant women, 100 diagnosed with preeclampsia and 100 healthy controls. Insulin resistance was assessed using the homeostasis model assessment (HOMA-IR), along with measurements of fasting insulin and glucose levels.

The results indicated that women with preeclampsia exhibited significantly higher HOMA-IR values compared to the control group (6.8 ± 2.1 vs. 3.5 ± 1.3, p < 0.001). Additionally, a higher prevalence of obesity and metabolic syndrome was noted among the preeclamptic group.

These findings suggest a strong association between insulin resistance and preeclampsia, highlighting the need for further investigation into the underlying mechanisms and potential therapeutic strategies to mitigate this risk.

Keywords: insulin resistance, preeclampsia, pregnancy, metabolic syndrome, HOMA-IR.