Impact of Maternal Lipid Profile in the Second Trimester of Pregnancy Outcomes and Complications

Abstract

This study investigates the relationship between maternal lipid profiles during the second trimester of pregnancy and subsequent pregnancy outcomes and complications. Alterations in lipid metabolism are common during pregnancy and may influence maternal and fetal health.
A cohort of 300 pregnant women was analyzed, measuring lipid profiles, including total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels during the second trimester. Outcomes assessed included gestational diabetes, hypertensive disorders, and neonatal birth weight. The results revealed significant associations between abnormal lipid levels and adverse pregnancy outcomes. Women with elevated triglycerides (>150 mg/dL) and cholesterol (>200 mg/dL) had higher incidences of gestational diabetes (20% vs. 8%) and hypertensive disorders (15% vs. 5%) compared to those with normal levels. Additionally, lower HDL levels were correlated with lower birth weights.

These findings suggest that monitoring maternal lipid profiles during the second trimester may be essential for identifying women at risk for complications, thereby facilitating early interventions to improve maternal and fetal health.
Keywords: maternal lipid profile, pregnancy outcomes, complications, gestational diabetes, hypertensive disorders.