THE PROGNOSTIC VALUE OF SERUM URIC ACID LEVELS IN ACUTE MYOCARDIAL INFARCTION: A RETROSPECTIVE STUDY

Abstract

Objective: This study aims to investigate the association between serum uric acid (SUA) levels and outcomes in patients with acute myocardial infarction (AMI), focusing on SUA's potential role as a prognostic marker. Methods: We conducted a retrospective cohort study using medical records from January 2018 to December 2023 across several healthcare institutions. Adult patients (≥18 years) diagnosed with AMI were included. Data on SUA levels, myocardial damage severity, and clinical outcomes (mortality, adverse events, rehospitalization) were analyzed. Exclusion criteria included incomplete records, significant renal disease, secondary myocardial infarction, and age <18 years. Statistical analyses were performed to determine the association between SUA levels and AMI outcomes.
Results: The study included 150 patients with a mean age of 62.5 years. SUA levels were significantly higher in patients with more severe myocardial damage. SUA levels ≥ 9.0 mg/dL were associated with a 60% incidence of severe myocardial damage compared to 15% in those with SUA levels < 5.0 mg/dL. Elevated SUA levels also correlated with increased short-term mortality (25% in SUA ≥ 9.0 mg/dL group) and adverse events. Long-term outcomes showed higher mortality (30%) and rehospitalization rates (45%) in patients with SUA ≥ 9.0 mg/dL.
Conclusion: Elevated SUA levels are associated with increased severity of myocardial damage and poorer short-term and long-term outcomes in AMI patients. SUA may serve as a useful prognostic marker in AMI management, potentially guiding risk assessment and treatment strategies. Further research is needed to explore the mechanisms underlying these associations and evaluate the benefits of SUA-targeted interventions. Keywords: Serum uric acid, acute myocardial infarction, prognosis, biomarkers, cardiovascular outcomes..