Pharmacological Effects of Methanolic Extracts of Mormordica Charantia in Vincristine Induced Peripheral Neuropathy

Abstract

To conclude, both methanolic extract of Mormordica charantia roots as well as ethanolic extract of Moringa oleifera leaves showed potential neuroprotective activity as they have effective inducible NOS (iNOS) and neuronal NOS (nNOS) inhibiting property, antioxidative and anti-inflammatory activity. The saponins obtained from methanolic extract of Mormordica charantia roots showed antinociceptive activity and amelioration of both nerve conduction velocity (NCV) and histopathological changes (sciaticnerve) after vincristine induced alteration.

Keywords: Mormordica charantia Methanolic extracts, Vincristine, peripheral neuropathy