FORMULATION AND EVALUATION OF RIFAMPICIN SOLID LIPID NANOPARTICLES

Abstract

The solid lipid nanoparticles (SLNs) are sub-micron sized colloidal carriers composed of physiological lipid dispersed either in water or in an aqueous surfactant solution. SLNs as colloidal drug carrier combine the advantages of polymeric nanoparticles, fat emulsions and liposomes. Rifampicin is bactericidal to M.tuberculosisand many other gram positive and negative bacteria. The solid lipid nanoparticles of rifampicin were prepared by ‘emulsion solvent diffusion method’. PVA (cold aqueous soluble) was used as shell material, Stearic acid as lipid core and Methanol and Chloroform as organic solvents. Processing parameters were optimized to achieve maximum yield and high quality of solid lipid nanoparticles of Rifampicin.

KEYWORDS: Solid lipid nanoparticles, SLN, Rifampicin.