Development of RP-HPLC Method for Simultaneous Estimation of Lornoxicam and Paracetamol in Combined Dosage Forms

Abstract

A simple, rapid reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of paracetamol and lornoxicam in bulk and pharmaceutical dosage forms. Determination of the different analytical parameters such as linearity, precision, accuracy, and specificity, limit of detection (LOD) and limit of quantification (LOQ) was done. The calibration curve was found to be linear for each analyte in the desired concentration range. The proposed method is highly sensitive, precise and accurate for paracetamol and lornoxicam respectively and hence the present method can be applied successfully for the quantification of active pharmaceutical ingredient (API) content in the combined formulations of paracetamol and lornoxicam.