Thiazoles: A Valuable Insight in to the Recent Advances and Biological Activities

Abstract

The heterocycle thiazole, which consists of Sulfur and Nitrogen atoms, plays a significant role in the study of medicine. Thiamine (Vitamin B1) and many other naturally occurring and synthetically produced substances of therapeutic significance have this core scaffold. The penicillin nucleus, of which thiazole is a crucial component, and some of its derivatives have showed antibacterial (sulfazole), antiretroviral (ritonavir), antifungal (abafungin), antihistamine, and antithyroid properties, demonstrating the flexibility of the thiazole nucleus. Recent uses as an anticancer (tiazofurin) and anthelmintic have greatly boosted the synthetic relevance of thiazole derivatives, its reduced forms, and condensed derivatives.

Key words: Thiazoles derivatives; Biological activities..