Preparation and Evaluation of Pioglitazone Tablet by Solid Dispersion Technique

Authors

  • Parag Sharma Research Scholar, Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan
  • Dr. Vijay Sharma Professor, Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan.
  • Dr. N. Ravindra Principal and Professor, Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan

DOI:

https://doi.org/10.32553/jddt.v11i3.468

Keywords:

Hypoglycemic drug, solubility, fusion method, bioavailability

Abstract

Pioglitazone is an oral hypoglycemic drug, used for the treatment of type 2 diabetes. The main objectives of this study were to improve aqueous solubility of Pioglitazone by preparing its solid dispersion by fusion method using various carriers that will improve its absorption and subsequent bioavailability. The prepared tablets (TF1-TF5) were evaluated for various parameters i.e.shape and size, weight variation, hardness, friability, disintegration time, drug content etc. The prepared tablet passed all the tests.Finally, it can be concluded that solid dispersion of Pioglitazone may be prepared to improve its solubility and dissolution. This will lead to better absorption and hence improved bioavailability of the drug (Pioglitazone).

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Published

2023-05-14

Issue

Section

Articles