Solubility Enhancement of Poorly Water- Soluble Drugs Using Solid Dispersion Method: A Review

Abstract

Solid dispersions have generated substantial attention as a technique of increasing the dissolution rate and hence the bioavailability of a variety of medications that are poorly soluble in water. Today, the pharmaceutical industry discovers up to 40% of novel chemical entities that are poorly soluble or lipophilic. Solid dispersions of insoluble in water pharmaceuticals in water-soluble carriers significantly minimise the occurrence of these difficulties and improve dissolution. Solid dispersion is one of the most promising methods for increasing solubility. The phrase "solid dispersion" refers to a collection of solid goods that have at least two distinct components, most often a hydrophilic matrix and a hydrophobic medication. The matrix might be crystalline or amorphous in nature. Class II medicines with limited solubility and high permeability are attractive candidates for bioavailability enhancement by solid dispersion, according to the biopharmaceutical categorization system. The purpose of this paper is to explore current achievements in the field of solid dispersion.

Keywords: Solid dispersions, solubility, carrier, Biopharmaceutical classification system.