Formulation and Evaluation of Elementary Osmotic Antidepressant Capsule

Abstract

The oral route of administration is considered as the most widely accepted route but the most evident drawback of the commonly used oral dosage forms like tablets and capsules is difficulty in swallowing, leading to patient’s incompliance particularly in case of paediatric, geriatric patients, dysphasic, bed ridden, and psychic patients. Thus, a new delivery system developed as in situ pore former osmotic drug delivery system. The purpose of present research work was to develop osmotic drug delivery of Imipramine. Imipramine has been selected as a model drug to study the effect of in-situpore former osmotic capsule because is a tricyclic antidepressant mainly used in the treatment of depression. 

Keywords: Osmotic, Capsule, Drug