COLON TARGETED DRUG DELIVERY SYSTEM FOR DICLOFENAC DRUG

Abstract

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery systems. Microspheres were prepared. The size range of the microsphere was 211 to 500 µm while drug content was between 70.40 and 91.50 % depending on the polymer used and the polymer ratio. It has good flow properties, while angle of repose was < 49^o, indicating free-flowing properties. The microspheres were spherical in shape with smooth and nonporous surface, polymers gave better sustained release (F5) than the others. Microspheres prepared with drug: EC: PAP show the highest drug content, possess good flow properties and surface morphology, as well as promising drug release for colon specific drug delivery of diclofenac sodium for possible treatment of colon disease.

Keywords:  Diclofenac, colon targeted delivery, controlled delivery, Ethyl cellulose