A REVIEW ON FORMULATION PARAMETER OF FAST DISSOLVING TABLET
Keywords:Fast mouth dissolving tablet;, Superdisintegrants, Orodispersible, Mouth dissolving tablets
Tablet is unit dosage form in which one usual dose of the drug has been accurately placed by compression. Liquid oral dosage forms, such as syrups, suspensions, emulsions, solutions and elixirs are usually designed to contain one dose of medication in 5 to 30 ml and the patient is then asked to measure his or her own medication using teaspoons, tablespoon or other measuring device. The choice of excipients in tablet formulations depends on the API, the type of tablet, the desired characteristics, and the manufacturing process used. This is especially important for immediate release products where rapid release of drug substance is required. A disintegrant can be added to a powder blend for direct compression or encapsulation. A Fast Mouth Dissolving Tablet (FMDT) can be defined as an oral solid dosage form which when placed on tongue, disintegrates rapidly, releasing the drug, which dissolves or disperses in the saliva and then swallowed. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down in to the stomach. A process in which water is sublimated from the product after freezing is called freeze drying. Freeze dried forms offer more rapid dissolution than other available solid products. Tablets produced by moulding are solid dispersions. Physical form of the drug in the tablets depends whether and to what extent it dissolves in the molten carrier. Spray drying technique is based upon a particulate support matrix and other components to form a highly porous and fine powder. Directly compressed tablet’s disintegration and solubilization depends on single or combined action of disintegrants, water-soluble excipients and effervescent agent, disintegrant efficacy is strongly affected by tablet size and hardness.
Keywords: Fast mouth dissolving tablet; Superdisintegrants; Orodispersible; Mouth dissolving tablets