A REVIEW ON COMPARATIVE STUDY OF ADVERSE DRUG REACTIONS BETWEEN AMLODIPINE AND LOSARTAN IN OUT-PATIENTS OF PRIMARY HEALTHCARE CENTRE

Abstract

ABSTRACT
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long term high blood pressure, however, is a major risk factor for coronary artery disease, stroke, heart failure, peripheral vascular disease, vision loss, and chronic kidney disease. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow. Amlodipine is used to treat chest pain (angina) and other conditions caused by coronary artery disease. Amlodipine is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Amlodipine is for use in adults and children who are at least 6 years old. Losartan was first angiotensin II blocker. Food and Drug Administration (FDA) approved it in 1995 as an antihypertensive. There has been great progress in understanding the effects of angiotensin II (AII) in the kidney and the benefits of blockade of AII at the AT1 receptor. Although losartan is now one of many angiotensin receptor blockers (ARBs), it was the first clinically used and has significantly contributed to both the physiologic understanding of AII and the clinical benefit of AII blockade.
KEY WORDS: Hypertension, Amlodipine, Losartan, calcium channel blocker