A REVIEW ON BILAYER TABLETS CONTAINING PARACETAMOL AS SR LAYER AND N-ACETYL CYSTEINE AS IR LAYER

Abstract

ABSTRACT
Oral route is the most popular route of drug delivery due to it is ease of administration patient compliance least sterility constraints and flexible design of dosage form. Bilayer tablet have some key advantages compared to conventional monolayer tablets. Such tablets commonly used to avoid chemical incompatibilities of formulation component by physical separation. bilayer tablets have enabled the Development of controlled delivery of active pharmaceutical ingredients with predetermined release profiles by combining layer with various release patterns or by combining slow release with immediate release layers. Bilayer tablets have some key advantages compared to conventional monolayer tablets For instance such tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation. In addition, bilayer tablets have enabled the development of controlled delivery of active pharmaceutical ingredients with predetermined release profiles by combining layers with various release patterns, or by combining slow-release with Immediate-release layers. The displacement tablet weight control principle is fundamentally different from the principle based upon compression force. When measuring displacement, the control system sensitivity does not depend on the tablet weight but depend on the applied pre compression force.
KEY WORDS: bilayer tablets, paracetamolN-acetyl cysteine, drug products