COMPARISON OF ERYTHROPOIETIN AND DARBEPOETIN IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL

Abstract

Chronic kidney disease (CKD), is a progressive loss of kidney function over several months to years and cause complications like anaemia. Erythropoiesis stimulating agents (ESAs) such as erythropoietin and darbepoetin are widely used as a first-line treatment for the management of renal anaemia in CKD patients . Treatment of anaemia with ESAs could reduce the need for red blood cell transfusion and improve outcome and quality of life (QOL).As there are not enough studies in Indian literature regarding the comparison of erythropoietin and darbepoetin in chronic kidney disease patients, the present review is undertaken. This review is designed to compare the effect of erythropoietin and darbepoetin by measuring serum Haemoglobin and creatinine in CKD patients .In review articles it is observed that erythropoietin and darbapoetin shows comparable effect in bringing Hb to normal ranges but there observe an increase in creatinine in some patients. Darbepoetin is a unique erythropoietic agent with an approximately threefold longer half-life than erythropoietin, allowing less frequent dosing than erythropoietin.

KEY WORDS: Anaemia, Chronic kidney disease, Erythropoietin, Darbepoetin , Haemoglobin, Creatinine.