NEW SPECTROPHOTOMETRIC DETERMINATION OFMETOCLOPRAMIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Abstract

The  new, selective and sensitive visible spectrophotometric method  have been developed for the estimation of Metoclopramide  in bulk and in pharmaceutical preparations. The amino group in Metoclopramide is diazotized with sodiumnitrite and hydrochloric acid at 0⁰C temperature. After diazotization, the diazonium salt is coupled with resorcinol. The orange coloured chromogen formed in the method is stable for more than 24 hours. The orange colouredchromogen is used to determine the Metoclopramide spectrophotometrically.

KEYWORDS: Spectrophotometric determination, Metoclopramide, Resorcinol and diazotization.