Effect of tramadol in elevated plus maze apparatus– A rodent model of anxiety.

Authors

  • Jayasree D Asst. Professor, Dept. of Pharmacology, Madha Medical College & Research Institute, Porur, Chennai-600112, Tamil Nadu, India.

Keywords:

Tramadol, Anxiety, Elevated plus maze apparatus.

Abstract

Anxiety is a widespread disorder in world wide. Some amount of anxiety always associated with depression. In this study we tested anti-anxiety effect of tramadol in Elevated plus Maze apparatus (EPM). Tramadol is synthetic centrally acting opioid analgesic.It is a weak µ opioid receptor agonist and also act as ananti-depressant by inhibiting uptake of noradrenaline and serotonin. Rats (150-250g) of either sex were randomly divided into 4 groups of 6 animals each. Tramadol was administered at two different doses (20, 40 mg/kg, i.p) 30 mints before conducting test. No of entries and time spent in both closed and open arm observed. The antianxiety effect of tramadol was compared to that of diazepam(2 mg/kg, i.p), in elevated plus maze apparatus (EPM).The result of the study shows that tramadol dose dependently increases entries and time in open arm (40mg/Kg) in EPM. Tramadol showed anti-anxiety activity in Elevated plus Maze apparatus.

 

Key words: Tramadol, Anxiety, Elevated plus maze apparatus.

Downloads

Published

2015-03-30

Issue

Section

Articles