Formulation & evaluation of voriconazole ointment for topical delivery

Abstract

The studies were conducted with an object to develop a desired ointment for treatment of fungal infection like eczema itching, purities’. Main objective of this study is to formulate the ointment with different ointment bases having good consistency, diffusion, antifungal and antiseptic properties. To assess the efficacy of formulations assay, spread ability, permeability, drug release, uniformity, viscosity, diffusivity, stability, and other physical characteristics were evaluated. The ointment base was prepared and formulation of ointment was done by incorporating the active ingredients in most effective ratio in the base by fusion method. The PEG ointments were prepared with changing the type of the liquid PEG (low molecular weight). Then, the viscosity and the voriconazole release from the prepared formulations were studied.

Keywords: Voriconazole, Polyethylene glycols, Antifungal activity.