Formulation and evaluation of tramadol and diclofenac sodium multimodal sustain release tablet dosage form

Abstract

Pain is treated using the unimodal pain management which are based on either central analgesic drug mechanism or other drug like nsaid. These drugs control the pain by central nervous system or peripheral nervous system.

But in body both system involve for the pain so for moderate to severe pain unimodal approach is not sufficient to address multimodal mechanism. But when we add peripheral anti-inflammatory drug then this multimodal drug combination provides pure pain relief for the treatment. Which prohibit ascending and descending modulation pain pathway message is inhibited by the opioid analgesics and at the site of injury where peripheral nocicepter and peripheral nerve present there NSAID require to relive the pain.

Here tramadol and diclofenac sodium tablet is preparing by wet granulation method and evaluated for various parameter like thickness of the tablet, hardness, weight variation cor uniformity, friability to solve transportation problem, drug content for evaluation. Drug release was carried out using USP type II apparatus at 80 rpm in 900ml of dissolution media for 10 hrs. Mean dissolution time is used to evaluate drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Tramadol hydrochloride and diclofenac sodium tablet were close to first order release system.

HPMC-15 is here using for sustain release of the tablet which provide long therapeutic action of the table for 10 to12 hour Dicalcium phosphate is add as a diluents. For osteoarthritis and rheumatoid arthritis and post surgical, pain, fracture, dislocation, tooth extraction and tooth carries this tablet will vary helpful for long time action and powerfully drug action. Unlikely patient compliance will also increase because the less repetition of dose administration is required.