FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF TIZANIDINE HYDROCHLORIDE

Abstract

The aim of this study was to formulate and evaluate the sustained release matrix tablet of Tizanidine hydrochloride. Tizanidine hydrochloride tablets were prepared by wet granulation technique using different polymers like propyl methyl cellulose (HPMC) K 100, ethyl cellulose and gaur gum alone or in combinations. Prepared tablets were evaluated for weight variation, hardness, friability, content uniformity and dissolution studies. % Cumulative drug release from all the prepared formulations were found to be in following order: F4 > F1 > F5 > F2 > F5 > F3. The result indicated that formulation (F4) containing mixture of two polymers HPMC K 100 and ethyl cellulose showed the release profile for 14 hours and high drug content.

KEYWORDS: Tizanidine hydrochloride, HPMC, ethyl cellulose, Sustain release, Matrix tablet