Matrix tablet- simplest method of sustaining drug action

Abstract

Matrix tablet were designed to achieve the sustained released of drug from dosage form. Sustained release of drug is required to prolong the duration of action of drug, thus reducing the dosing frequency. Matrix tablet were designed first in sustained release dosage forms. Matrix tablet offers least manufacturing cost among other sustained release formulations. Matrix tablet are designed by dispersing drug in hydrophobic or hydrophilic polymer. The release of drug from such system may be dissolution or diffusion controlled or both. Various type of factor and method of manufacturing affect the drug release from tablet matrix. Matrix tablet are widely used due to simplicity of formulation and easiest in use. The basic rationale of matrix tablet is to optimize the biopharmaceutical pharmacokinetics and pharmacodynamics properties of drug in dosage form in such a way that it utility maximized and side effects are reduced to cure disease.

Key words: Sustained released, Matrix tablet, pharmacokinetics and pharmacodynamics.