NEW SPECTROPHOTOMETRIC DETERMINATION OF LAMOTRIGINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Abstract

The  new, selective and sensitive visible spectrophotometric method  have been developed for the estimation of Lamotrigine  in bulk and in pharmaceutical preparations. The amino group in lamotrigine is diazotized with sodiumnitrite and hydrochloric acid at 0⁰C temperature . After    Diazotisation ,the  diasoniumsalt, the diazonium salt is coupled with resorcinol. The orange coloured chromogen in the method is stable for more than 24 hours with wavelength max. 410nm. The orange coloured chromogen is used to determine the Lamotrigine spectrophotometrically.

KEYWORDS: Spectrophotometric determination, lamotrigine, Resorcinol and diazotization.