FORMULATION AND IN VITRO EVALUATION OF CEFIXIME MICROSPHERES PREPARED MULTIPLE EMULSION TECHNIQUE

Abstract

The purpose of the research work was to prepare and evaluate the microspheres of cefixime as a model drug by multiple emulation method with gelatin as polymer in various proportions. A total of six formulations were prepared i.e. F1, F2, F3, F4, F5 and F6. The microspheres were evaluated for micromeritic properties, particle size, % yield, Drug content and Drug release. The size or average diameter of prepared microspheres was in between 4μm-16 μm. Cefixime release from these microspheres was sustained by various rations of gelatin. The formulation F2 and F5 showed consistent drug release for up to 8 h time period. Among all the formulations, F4 contains gelatin ratio (1:4) showed the reproducible results with best release profile and good surface morphology.

KEYWORDS: Cefixime, gelatin, Tween-20, isopropyl alcohol.