Anxiolytic Activity of Grewia Tiliaefolia in Stress Induced Albino Rats

Abstract

Anxiety usually refers to the experience of fear, apprehensiveness, nervousness, panic, restlessness, tension, and agitation. The percentage of anxiety among people increasing day by day, hence need to focus on it. Anxiety disorders are the most common class of mental disorder in adult.  Specific phobias and social anxiety disorder are very common among this disorder. Some Neurotransmitters including serotonin, dopamine, noradrenaline and GABA are responsible for generation anxiety.  Serotonin modulators and benzodiazapines are mostly used to improve anxiety. The present paper discusses anti-anxiety potential of Grewia tiliaefolia leaves. Grewia tiliaefolia leaves contains flavonoids, steroids, tannins, saponins  and alkaloids. Flavonoids were the major constituent for the anxiolytic activity. The effect of methanolic extract of Grewia tiliaefolia leaves(200mg/kg and 400mg/kg, orally, daily, 21 days) on anxiolytic activity was assessed by using Modified elevated plus maze apparatus and Light-dark box apparatus. Anxiety activity in rats was induced by restraint stress. The results shows that Open arm entries were increased and closed arm entries were decreased in modified elevated plus maze apparatus(MEPMA). Light box entries were increased and dark box entries were decreased  in light and dark box model(LDB). Thus we can conclude that methanolic extract of Grewia tiliaefolia leaves exhibits significant anxiolytic activity at low dose (200mg/kg) and high dose (400mg/kg). Thus Grewia tiliaefolia leaves is a promising herbal option in the pharmaceutical world.

Keywords: Grewia tiliaefolia, Anxiety, Elevated plus maze apparatus, light and dark box apparatus, Anxiolytic activity